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【公司名稱】 廣州健侖生物科技有限公司
【市場(chǎng)部】    楊永漢

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【騰訊  】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

利用小鼠朊病毒疾病的模型，研究人員確定這些新生神經(jīng)元產(chǎn)生的時(shí)間進(jìn)程，以及它們?nèi)绾稳谌氪竽X回路中。雖然這種自我修復(fù)機(jī)制能夠有效維持疾病早期和中間階段的神經(jīng)功能，但是在更高級(jí)的階段中卻無(wú)法維持。這突出一個(gè)為了保護(hù)有益增強(qiáng)神經(jīng)發(fā)生的影響的潛在干預(yù)治療的時(shí)間窗口。
戈麥斯 - 尼古拉博士說(shuō)：“這項(xiàng)研究顯示，大腦的潛能有助于協(xié)調(diào)自我修復(fù)反應(yīng)。繼續(xù)這方面的研究開(kāi)辟新的途徑，確定哪些特殊信號(hào)有助于促進(jìn)神經(jīng)發(fā)生反應(yīng)的增加，專注于神經(jīng)發(fā)生作為一種促進(jìn)缺失神經(jīng)元再生的治療方法。”
這項(xiàng)研究發(fā)表于《大腦》雜志上，由歐盟第七框架計(jì)劃和醫(yī)學(xué)研究理事會(huì)(MRC)資助。
已知由大腦中的海馬體協(xié)調(diào)學(xué)習(xí)和記憶能力。在誕生之前，大腦的大部分已經(jīng)發(fā)育完畢。此后還要經(jīng)歷兩個(gè)發(fā)育高峰時(shí)期，一個(gè)是兒童期，一個(gè)是青春期，這兩個(gè)階段大腦發(fā)育快速。在過(guò)去20年間，研究證實(shí)，成人的神經(jīng)再生主要發(fā)生在海馬體中。
該研究通過(guò)一個(gè)動(dòng)物模型發(fā)現(xiàn)，核受體TLX基因過(guò)量表達(dá)時(shí)，試驗(yàn)對(duì)象聰明且學(xué)習(xí)起來(lái)更快，另外所獲得的信息能持續(xù)得更持久。

Using a model of mouse prion disease, researchers determine the timing of these newborn neurons and how they integrate into the brain's circuitry. Although this self-healing mechanism can effectively maintain the neurological function of the early and middle stages of the disease, it can not be maintained at a more advanced stage. This highlights a time window for potential interventions to protect the beneficial effects of neurogenesis.
Dr. Gomez-Nicola said: "This study shows that the brain's potential helps to coordinate self-healing reactions." Continuing studies in this area have opened up new avenues to determine which particular signals contribute to promoting an increased neurogenic response , Which focuses on neurogenesis as a treatment for de novo neuron regeneration. "
The study, published in the journal Brain, is funded by the EU's Seventh Framework Program and the Medical Research Council (MRC).
It is known that the hippocampus in the brain coordinates the learning and memory abilities. Before birth, much of the brain has been developed. There are two more developmental periods to follow, one in childhood and one in adolescence, during which time the brain develops rapidly. In the past 20 years, studies have confirmed that adult nerve regeneration occurs mainly in the hippocampus.
The study, based on an animal model, found that when the nuclear receptor TLX gene is overexpressed, subjects are smart and learn faster, and the information they receive lasts longer.